ABSTRACT
In the WHO new road map for neglected tropical diseases 2021—2030, the disease-specific targets are classified into control, elimination as a public health problem, elimination and eradication, and taeniasis and cysticercosis are targeted for control. The overall prevalence of taeniasis and cysticercosis is low in China, and varies remarkably in regions and populations; however, there are many challenges for elimination of taeniasis and cysticercosis in China. Based on previous taeniasis and cysticercosis control programs, developing a sensitive taeniasis and cysticercosis surveillance-response system, updating criteria for diagnosis of taeniasis and cysticercosis, proposing a national guideline for treatment of taeniasis and cysticercosis, and strengthening interdisciplinary and intersectoral communications and collaborations are urgently needed under the One Health concept.
ABSTRACT
Objective To understand the prevalence of soil-borne nematode infections among residents living in urban/town areas of China, so as to provide insights into the control and elimination of soil-borne nematodiasis. Methods A total of 5 epidemic areas were classified in China according to the prevalence of human Clonorchis sinensis infections captured from the 2014–2015 national survey on major human parasitic diseases in China, and the total sample size was estimated according to the binomial distribution and Poisson’s distribution. Then, the total sample size was allocated proportionally to each province (autonomous region, municipality) of China based on the percentage of residents living in urban and town areas, and the number of survey sites in each province (autonomous region, municipality) was proportionally assigned according to the percentages of residents living in urban and town areas. Then, stratified sampling was performed at county, township and community levels according to the number of sampling sites in each province (autonomous region, municipality), and the survey site (community) was defined as the smallest sampling unit. All permanent residents in the survey sites were selected as the study subjects, and their stool samples were collected for identification and counting of parasite egg using a Kato-Katz technique. The prevalence and intensity of each parasite species were calculated. Results From 2014 to 2015, among the 133 231 residents detected in 31 provinces (autonomous regions, municipalities) of China, the overall prevalence of soil-borne nematode infections was 1.23% (1 636/133 231), and the prevalence rates of hookworm, Ascaris lumbricoides and Trichuris trichiura infections were 0.77% (1 032/133 231), 0.32% (426/133 231) and 0.17% (224/133 231), respectively. The highest prevalence of soil-borne nematode infections was seen in Jiangxi (4.03%, 82/2 034) and Chongqing (4.03%, 524/13 012), followed by in Hainan (3.47%, 72/2 075). The prevalence of soilborne nematode infections was 1.07% (662/62 139) in men and 1.37% (974/71 092) in women, and the greatest prevalence was found in residents at ages of 65 to 70 years (2.56%, 219/8 569). With regard to occupations and education levels, herdsmen (2.47%, 2/81) and illiterate residents (3.33%, 226/6 795) were found to have the highest prevalence of soil-borne nematode infections, respectively. In addition, mild infections were predominantly identified in hookworm-, A. lumbricoides- and T. trichiura-infected individuals (all > 90%). Conclusions The overall prevalence of soil-borne nematodiasis remains low in urban and town areas of China; however, human infections are widespread. According to the epidemiological features, health education combined with deworming are recommended to reduce the prevalence of soil-borne nematode infections among residents living in urban and town areas of China.
ABSTRACT
Objective To understand the epidemic status of Enterobius vermicularis infections among children aged 3 to 9 years in China, so as to provide scientific basis for the formulation of the prevention and control strategies for enterobiasis. Methods The national surveillance of enterobiasis was performed in 736 national surveillance sites (counties) from 30 provinces (municipalities/autonomous regions) in China from 2016 to 2018. All surveillance sites were classified into parts according to the geographical directions, including the eastern, western, southern, northern and middle parts, and a township was randomly selected from each part. Then, an administrative village was randomly selected from the township, and 200 permanent residents at ages of over 3 years living in the administrative village were randomly selected using the cluster sampling method. A total of 1 000 residents were examined in each surveillance site. E. vermicularis infections were detected among children at ages of 3 to 9 years using the modified Kato-Katz technique and the adhesive cellophane-tape perianal swab method, and the prevalence of infections was calculated and compared. Results The prevalence of E. vermicularis infections was 2.50%, 2.84% and 2.46% among children at ages of 3 to 9 years in the 736 surveillance sites from 30 provinces (municipalities/autonomous regions) in China from 2016 to 2018, and there was no gender-specific prevalence of E. vermicularis infections (P > 0.05). Enterobiasis was main prevalent in the southern and southwestern part of China (Jiangxi, Guangxi, Guangdong, Sichuan, Fujian, Chongqing and Hainan), with 5.00% prevalence and greater, and the highest prevalence was seen in Jiangxi and Guangxi for successive 3 years. In addition, the prevalence of E. vermicularis infections was higher in children with the Han ethnicity than in those with the minority ethnicity, and a high prevalence was found in children at ages of 4 to 7 years, and a low prevalence seen in children at ages of 3, 8 and 9 years. Conclusions The prevalences of E. vermicularis infections have not changed much among children at ages of 3 to 9 years in China from 2016 to 2018, and high prevalence is seen in southern and southwestern China, which should be given a high priority.
ABSTRACT
Ascariasis once was a common disease in rural areas of China. It is showed that the average infection rate of Ascaris lumbricoides in China was 1.36% according to the results of the national survey of important human parasitic diseases in 2015. Although the prevalence of ascariasis has been greatly reduced as compared with that at the beginning of this century, ascariasis is still widespread in China. The Diagnostic Criteria for Ascariasis (WS/565–2017) was promulgated and implemented by the former National Health and Family Planning Commission on August 1st, 2017. This Diagnostic Criteria for Ascariasis is composed of six chapters, including the Range of Application, Terms and Definitions, Diagnostic Basis, Diagnostic Principle, Diagnostic Standard, and Differential Diagnosis. Four informative appendixes (etiology, epidemiology, clinical manifestation, and differential diagnosis) and one normative appendix (laboratory examination) are appended. The criteria provide the technical reference for diagnosis of ascariasis in medical institutions and disease control institutions. Combined with the current epidemic situation of ascariasis in China, this paper interprets the main contents of the Diagnostic Criteria for Ascariasis (WS/565–2017), so as to promote its learning and implementation.
ABSTRACT
Objective To understand the basic information and epidemic characteristics of new cases of cysticercosis in Dali Prefecture, Yunnan Province, so as to provide the evidence for formulating the prevention and control strategy of cysticercosis. Methods The data of inpatients in the Dali Parasitic Disease Prevention and Control Center from 2014 to 2017 were collected and the eligible data of new cases of cysticercosis were analyzed by the epidemiological method. Results There were 1 552 patients with cysticercosis, including 549 new cases of cysticercosis. Among the new cysticercosis patients, most were neurocysticer-cosis cases (484 / 549, 88.16%). The symptoms included epilepsy and headache (51.73%), headache (40.98%), and dizziness (18.76%). The new cysticercosis patients were mainly middle-aged male farmers of Bai nationality, and they were distributed in all counties (cities) of Dali Prefecture, especially in Eryuan County (26.78%), and Dali City (19.49%). The annual incidence rate was 4.423/105 in 2014, 3.837/105 in 2015, 3.765/105 in 2016, and 3.442/105 in 2017, and there was no significance among the different years’incidence ( χ2 = 4.595, P > 0.05). Conclusion Dali Prefecture is still an endemic area of cysticercosis. Therefore, the monitoring, prevention and control of the disease should be strengthened.
ABSTRACT
Ascariasis once was a common disease in rural areas of China. It is showed that the average infection rate of Ascaris lumbricoides in China was 1.36% according to the results of the national survey of important human parasitic diseases in 2015. Although the prevalence of ascariasis has been greatly reduced as compared with that at the beginning of this century, ascariasis is still widespread in China. The Diagnostic Criteria for Ascariasis (WS/565–2017) was promulgated and implemented by the former National Health and Family Planning Commission on August 1st, 2017. This Diagnostic Criteria for Ascariasis is composed of six chapters, including the Range of Application, Terms and Definitions, Diagnostic Basis, Diagnostic Principle, Diagnostic Standard, and Differential Diagnosis. Four informative appendixes (etiology, epidemiology, clinical manifestation, and differential diagnosis) and one normative appendix (laboratory examination) are appended. The criteria provide the technical reference for diagnosis of ascariasis in medical institutions and disease control institutions. Combined with the current epidemic situation of ascariasis in China, this paper interprets the main contents of the Diagnostic Criteria for Ascariasis (WS/565–2017), so as to promote its learning and implementation.
ABSTRACT
Objective To understand the basic information and epidemic characteristics of new cases of cysticercosis in Dali Prefecture, Yunnan Province, so as to provide the evidence for formulating the prevention and control strategy of cysticercosis. Methods The data of inpatients in the Dali Parasitic Disease Prevention and Control Center from 2014 to 2017 were collected and the eligible data of new cases of cysticercosis were analyzed by the epidemiological method. Results There were 1 552 patients with cysticercosis, including 549 new cases of cysticercosis. Among the new cysticercosis patients, most were neurocysticer-cosis cases (484 / 549, 88.16%). The symptoms included epilepsy and headache (51.73%), headache (40.98%), and dizziness (18.76%). The new cysticercosis patients were mainly middle-aged male farmers of Bai nationality, and they were distributed in all counties (cities) of Dali Prefecture, especially in Eryuan County (26.78%), and Dali City (19.49%). The annual incidence rate was 4.423/105 in 2014, 3.837/105 in 2015, 3.765/105 in 2016, and 3.442/105 in 2017, and there was no significance among the different years’incidence ( χ2 = 4.595, P > 0.05). Conclusion Dali Prefecture is still an endemic area of cysticercosis. Therefore, the monitoring, prevention and control of the disease should be strengthened.
ABSTRACT
Objective To establish an evaluation system for the field assessment of the Kato-Katz technique in detecting soiltransmitted nematodes, so as to provide insights into the field application of the Kato-Katz technique. Methods The initial evaluation indicators were determined through literature search, brainstorming and expert consultation. The evaluation indicatorswere improved and the weight of each indicator was decided through three rounds of expert consultation by using the Delphimethod. In addition, the expert authority coefficient and the coordination coefficient of each indicator were calculated at eachround of expert consultations. Results The recovery rates of the questionnaire were 100.00%, 100.00% and 89.29% at the firstto the third round of the expert consultations, respectively, and the expert authority coefficients were all more than 0.85 at eachround. The final evaluation system included 4 first-level indicators and 15 second-level indicators. In the first-level indicators, “detecting effect” and “funds investment” had the mean weighted value of 4.53 and 4.49, which were relatively higher than that of“person-time investment“ and "operability“ (both 4.34). Among the second-level indicators under each first-level indicator, thefour most significant indicators included “ability of personnel in egg discrimination“, “cooperation of village cadres and doctors“,“Person-time on testing“ and “organizational start-up cost“, with the mean weighted values of 4.74, 4.43, 4.39 and 4.17, respectively. The coordination coefficients were 0.39 to 0.65, 0.28 to 0.58 and 0.45 to 0.65 at the first to the third round of the expertconsultations, respectively, and there were significant differences in the coordination coefficients at all three rounds of the consultations (all P < 0.05). Conclusions An evaluation system for the field assessment of the Kato-Katz technique in detecting soiltransmitted nematodes is successfully established, among which “ability of personnel in egg discrimination“ and “cooperation ofvillage cadres and doctors“ have the greatest mean weighted values of the significance.
ABSTRACT
The current status of soil-transmitted nematodiasis in China is analyzed. The achievements in prevention and control of soil-transmitted nematodiasis are illustrated. Moreover, the challenges in condition of the decline of soil-transmitted nematodiasis in China are demonstrated. Finally, the working principals for prevention and control of soil-transmitted nematodiasis in the new period are proposed, combining with the health poverty alleviation project, focusing on the goals of control plan for important parasitic diseases, establishing monitoring system for soil-transmitted nematodiasis, and implementing the principles of precise prevention and control.
ABSTRACT
The criteria for the Kato-Katz thick smear are compiled following the Management Measures for Health Criteria and GBT 1.1–2009 Standardization Working Guidelines. The criteria are composed of five chapters, including the range of application, terms and definitions, equipments, reagent materials, and testing procedures. Three informative appendices (identification of helminth eggs in human faeces, counting method of eggs in Kato-Katz thick smear, and other considerations) are appended. The criteria have been issued by the National Health and Family Planning Commission of the People’s Republic of China, it provides a technical reference for the detection of helminth eggs in human faeces in medical institutions and disease prevention and control institutions.
ABSTRACT
Objective To understand the epidemic status of clonorchiasis and awareness of prevention and control knowledge in Xinfeng County of Jiangxi Province, so as to provide the evidences for control measures. Methods The baseline survey was carried out with a clue in vestigation of raw-fish eating behavior in potential endemic areas in 2016.The residents were examined by stool tests. The metacercariae of Clonorchis sinensis in fish, the rediae and cercariae in freshwater mollusk were detected. The feces samples of cats, dogs and pigs were collected and examined by sedimentation technique. Meanwhile, the epidemic factors, health knowledge and behavior were also surveyed. Results The residents in 26 villages had the habit of eating raw freshwater fish, and 19.51% of the respondents had this habit. The average infection rates of the population, Parafossarulus striatulus, freshwater fishes and reservoir hosts were 21.56%, 0, 8.24% and 2.27%, respectively. The infection rate of the population increased with age. There was a significant positive correlation between the behavior and the infection rate of the population (r = 0.88, P < 0.01). Only 11.46% of the respondents knew that eating raw-fish might cause C. sinensis infection, and 5.28% of them knew that C. sinensis was harmful to health. Conclusions Twenty-six villages in five townships were endemic areas of clonorchiasis in Xinfeng County. The permanent solution of prevention and control of clonorchiasis is to strengthen the health education and change the habit of raw-fish eating gradually.
ABSTRACT
The criteria for the Kato-Katz thick smear are compiled following the Management Measures for Health Criteria and GBT 1.1–2009 Standardization Working Guidelines. The criteria are composed of five chapters, including the range of application, terms and definitions, equipments, reagent materials, and testing procedures. Three informative appendices (identification of helminth eggs in human faeces, counting method of eggs in Kato-Katz thick smear, and other considerations) are appended. The criteria have been issued by the National Health and Family Planning Commission of the People’s Republic of China, it provides a technical reference for the detection of helminth eggs in human faeces in medical institutions and disease prevention and control institutions.
ABSTRACT
Objective To understand the epidemic status of clonorchiasis and awareness of prevention and control knowledge in Xinfeng County of Jiangxi Province, so as to provide the evidences for control measures. Methods The baseline survey was carried out with a clue in vestigation of raw-fish eating behavior in potential endemic areas in 2016.The residents were examined by stool tests. The metacercariae of Clonorchis sinensis in fish, the rediae and cercariae in freshwater mollusk were detected. The feces samples of cats, dogs and pigs were collected and examined by sedimentation technique. Meanwhile, the epidemic factors, health knowledge and behavior were also surveyed. Results The residents in 26 villages had the habit of eating raw freshwater fish, and 19.51% of the respondents had this habit. The average infection rates of the population, Parafossarulus striatulus, freshwater fishes and reservoir hosts were 21.56%, 0, 8.24% and 2.27%, respectively. The infection rate of the population increased with age. There was a significant positive correlation between the behavior and the infection rate of the population (r = 0.88, P < 0.01). Only 11.46% of the respondents knew that eating raw-fish might cause C. sinensis infection, and 5.28% of them knew that C. sinensis was harmful to health. Conclusions Twenty-six villages in five townships were endemic areas of clonorchiasis in Xinfeng County. The permanent solution of prevention and control of clonorchiasis is to strengthen the health education and change the habit of raw-fish eating gradually.
ABSTRACT
Objective To establish an evaluation system for health education products of parasitic diseases by using a Del-phi method,so as to provide references for the evaluation of health education products.Methods An expert panel was estab-lished and evaluation indicators were determined by brainstorming and face-to-face discussion,then the weight of each evalua-tion indicator was determined through a two-round Delphi method and the evaluation system was established.Results The eval-uation indicators for material products,graphic design products and audio-visual products were established respectively by ex-pert panel.Four first indicators and 12 second indicators were included in each type of products.The consensus was achieved fol-lowing the two rounds of expert consultation among 23 knowledgeable and experienced experts,who considered"scientificity"and"acceptability"to be the most important of all the first indicators,and"information accuracy"and"behavioral guidance"of all the second indicators.Conclusion A scientific and rational evaluation system is established,and it can be used in compre-hensive evaluation of health education products for parasitic diseases.
ABSTRACT
Cysticercosis refers to a parasitic infection caused by the larvae of pork tapeworm Taenia solium.It is a parasitic zoonosis and listed by the World Health Organization(WHO)as one of the neglected tropical diseases.Cysticercosis is spread-ing all over the world through globalization and it mainly epidemic in developing countries.In the southwest and minority nation-ality areas of China,as a result of the low level of medical and health care,and the unchangeable diet custom,there are still many cases of cysticercosis,which is manifested as a local high prevalence.Neuroimaging is the preferred method for cysticerco-sis diagnosis,and by using CT and MRI scans it is possible to visualise the infecting cysticerci and assess their number and loca-tion within the central nervous system(CNS).The immunological assay is also required in the diagnosis.At present,the preven-tion and control of cysticercosis is still relatively weak.In this paper,the current status and research progress of cysticercosis are reviewed,and further suggestions on the prevention and control of cysticercosis are put forward.
ABSTRACT
<p><b>OBJECTIVE</b>To examine Clonorchis sinensis infection in China and evaluate the effectiveness of efforts to prevent and control it, two nationwide surveys were undertaken in 31 provinces, autonomous regions, and municipalities (PAMs) during 1988-92 (the 1990 survey) and during 2001-04 (the 2003 survey).</p><p><b>METHODS</b>During the period 2001-04, two sampling methods were applied. The first method repeated the stratified cluster random sampling used in the 1990 survey; the second method applied two-characteristic stratified cluster random sampling in 27 PAMs-the 2003 endemic area (EA) survey. The Kato-Katz thick smear method was used for the nationwide survey.</p><p><b>RESULTS</b>The infection rates of Clonorchis sinensis in the 1990 and 2003 surveys were 0.311% and 0.579%, respectively. The infection rate was 2.40% in the 2003 EA survey, and it was estimated that 12.49 million people in China were infected with Clonorchis sinensis.</p><p><b>CONCLUSION</b>The 2003 survey showed that the standardized infection rate of Clonorchis sinensis increased by 74.85% compared with the 1990 survey. The infection rate in males was higher than in females; the infection rate among people eating raw fish or eating out frequently was higher than among those who did not.</p>
Subject(s)
Animals , Female , Humans , Male , China , Epidemiology , Clonorchiasis , Epidemiology , Parasitology , Clonorchis sinensis , Cluster Analysis , Health SurveysABSTRACT
<p><b>OBJECTIVE</b>In order to accumulate experiences for improving the efficiency in serological tests, the present study on mixed testing of serum samples was performed by taking the serological test of trichinellosis and toxoplasmosis as the examples, and had proved the effects on cost-effectiveness of seroepidemiological survey of parasitic disease with method of mixed-samples test.</p><p><b>METHODS</b>According to the binomial distribution principle, to develop an approach to the feasibility of mixed testing of serum samples, and to work on a cost-effectiveness analysis of one-by-one testing and mixed testing using hygienic economic analysis method was performed. For serological test of trichinellosis and toxoplasmosis, 3 kinds of mixed testing methods, namely 3 serum sample mixture, 5 serum sample mixture and 10 serum sample mixture, were performed.</p><p><b>RESULTS</b>The results showed that all the 3 kinds of mixed tests of trichinellosis and toxoplasmosis showing positive result if only 1 weak positive serum sample were mixed with. When the serum samples being mixed were all negative ones, then among the 24 groups tested with each kind of negative serum sample mixture of trichinellosis (3 serum samples, 5 serum samples and 10 serum samples), they all showed negative. However, among the 12 groups tested with 2 kinds of negative serum mixture of toxoplasmosis (3 serum samples and 5 serum samples), all showed negative while among the 18 groups tested with the 10 serum sample mixture, 16 groups showed negative and 2 were positive. The mixed testing of trichinellosis and toxoplasmosis showed that the efficiency of mixed testing was related to the serological positive rate of the parasitic diseases to be examined. When serological positive rate was 10%, the efficiency of mixed testing was higher in 4 serum sample group. When serological positive rate was 1%, the efficiency of mixed testing was higher in 10 serum sample group and when serological positive rate was 0.1%, the in crease of the size of mixed serum samples could decrease the number of testing, but the prerequisite was that there must be one positive sample, so that the positivity for all the mixed tests could be detected. If mixed testing were performed on all negative samples, no positivity could be detected.</p><p><b>CONCLUSION</b>The result of cost-effectiveness analysis demonstrated that for seroepidemiological survey of parasitic diseases, the cost for mixed testing was low, especially when the serological positive rate was expected low (< or = 1%, thus the mixed testing could save a large amount of the cost.</p>